Chemicals & Small Molecules

MitoTracker Orange CMTMRos, a fluorescent dye that labels mitochondria in live cells by utilizing the mitochondrial membrane potential (Ex/Em: 551/576 nm) [1].

MK-8527, an HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI), exhibits a similar inhibitory mechanism to ISL [1].

Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.

NIR-797-isothiocyanate is a versatile dye employed extensively across various scientific and industrial sectors. As a critical tool in biological experiments, this dye enables the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, examination of tissue pathology, and monitoring of microorganisms. Its applications extend from fundamental research to a broad spectrum of clinical diagnostics. Additionally, NIR-797-isothiocyanate finds usage in traditional industries like textile dyeing and in innovative areas including functional textile processing, food coloring, and dye-sensitized solar cells.

NTPO trisodium induces DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are mitigated by base excision repair (BER) but not by nucleotide excision repair (NER) [1].

Rose bengal lactone (C.I. Solvent Red 141) is a rose bengal lactone stain commonly used to stain the nuclei of plant and animal cells.

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is employed for labeling proteins on the external leaflet of intact exosomes and features an extended spacer arm between the biotin and the amine-reactive linker. This elongated linker is designed to mitigate steric hindrance, thereby enhancing labeling efficiency on the densely populated exosome surface [1] [2].

TI17, an inhibitor of the thyroid hormone receptor-interacting protein Trip13, possesses anticancer activity by effectively inhibiting multiple myeloma (MM) cell proliferation and inducing cell cycle arrest and apoptosis. Trip13, an AAA-ATPase mediating double-strand break (DSB) repair, is inhibited by TI17, resulting in increased DNA damage [1].

Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.