Chemicals

Squalene is a naturally occurring triterpenoid synthesized from two molecules of farnesyl diphosphate (FPP) by squalene synthase. Echelon's squalene has been further purified to remove oxidized byproducts.Featured in publications1) Howlader DR Das S Lu T Hu G Varisco DJ Dietz ZK Walton SP Ratnakaram SSK Gardner FM Ernst RK Picking WD and Picking WL (2021) Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas Aeruginosa. Front. Pharmacol. 12:706157. doi: 10.3389/fphar.2021.706157

2 3-Oxidosqualene is an important intermediate in the biosynthesis of membrane sterols being converted to lanosterol by 2 3-oxidosqualene cyclase. The (S)-enantiomer is formed by oxidation of squalene by monooxygenase. 2 3-(R)-oxidosqualene is an inhibitor of lanosterol synthase Powered by Bioz See more details on Bioz

2 3 22 23-Dioxidosqualene (mixture of diastereomers) is a substrate for oxidosqualene cyclase forming 24 25-oxidolanosterol. Powered by Bioz See more details on Bioz

Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number

PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

FKBP12 PROTAC dTAG-13 (dTAG-13) is a heterobifunctional degrader that targets FKBP12F36V with FKBP12F36V expressed in-frame with a protein of interest, and selectively degrades the BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to the E3 ubiquitin ligase CRBN.

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.

PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.