Chemicals

Azide functionalized Dextran is one of Nanocs premier reactive dextran conjugates. These azido dextrans are reactive toward alkyne or dibenzylcyclooctyne (DBCO) groups via so called Click Chemistry. Nanocs provides a variety of azide functionalized dextran products with molecular weight ranged from 3,000 Da to 2,000 KDa. These functional dextrans were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo. Azido dextrans are water soluble and they can react with alkyne or cyclooctyne in aqueous solution. Dextrans are naturally synthesized polysaccharides with good water solubility, low toxicity and varied molecular weights. Dextrans modified with dyes and other biomolecules have been successfully used as long-term tracers for live cells.

DNP Dextran (2,4-Dinitrophenyl conjugated to Dexran) is one of Nanocs DNP Dextran conjugates that can be used for immunoassay development. DNP is a frequently used heptan that has strong absorption around 360 nm. Nanocs provides a number of DNP conjugates that can be used for different applications. These DNP conjugates were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Nanocs provides a variety of chemically functionalized and bioconjugated Heparin with different functionality. These functional Heparin products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Nanocs provides a variety of chemically functionalized and bioconjugated Poly-L-lysine with different functionality. These functional polylysine products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Nanocs provides a variety of chemically functionalized and bioconjugated transferrin with different functionality. These functional transferrin products were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo.

Synercid complex, Dalfopristin-Quinupristin complex

Synercid complex, Dalfopristin-Quinupristin complex

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes fungi and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 2Z 6E-farnesyl diphosphate is formed by (2Z 6E)-farnesyl diphosphate synthase catalyzed condensation of IPP with geranyl diphosphate (GPP). Z-FPP is the precursor of decaprenyl diphosphate which has a central role in the biosynthesis of the mycobacterial cell wall.

Phytyl diphosphate is the precursor in the biosynthesis of tocopherol (Vitamin E) and phylloquinol in plants. It is formed by hydrolysis of the phytyl side chain on chlorophyll to phytol followed by phosphorylation by the kinases VTE5 & VTE6.