Labelling

Thiazole Orange is an asymmetric cyanine dye whose fluorescence highly depends on the local environment. Thiazole Orange is essentially dark in solution; however, its fluorescence increases a thousandfold when Thiazole Orange is introduced into double-stranded DNA and RNA (dsDNA or dsRNA). The maximum absorption of Thiazole Orange in complex with DNA is 509 nm, and the maximum emission is 532 nm. Thiazole Orange solution is widely used for determining the percentage of reticulocytes in human peripheral blood with microscopy and flow cytometry. We also offer the ready-to-use solution of Thiazole Orange LumiCell Reticulocyte Stain for this purpose.

sulfo-Cyanine3 dimethyl is a non-functionalized, water-soluble cyanine dye with bright yellow fluorescence. The dye can be used as a non-reactive fluorophore for control experiments, calibration, and other technical applications.

BP Lipid 370 is a novel lipid analog which features a unique 3-hydroxymethyl azetidine ionizable group with an ester linkage to two adipate ester branched tails. The head group also features a primary hydroxyl group for further derivativzation or to increase enhance surface properties. This lipid may be used in the formulation of lipid nanoparticles for drug or mRNA delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

14:0 PEG PE, MW 2,000 is a PEG-modified phosphatidylethanolamine used in liposome creation of sterically stabilized liposomes with low reticuloendothelial system uptake and bolstered circulation duration to target cells.

BP Lipid 389 features a unique 2-hydroxyethyl piperazine head group with an ester linkage to two oleic fatty acid tails. This lipid may be used in the formulation of lipid nanoparticles drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Our potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for α1A adrenergic receptor (Ki =28.3 nM measured in radioligand binding assay) and selectivity over α2A (Ki =1081 nM measured in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy or high content screening.

Our potent and selective hα1A adrenergic receptor fluorescent antagonist shows high affinity for alpha 1 adrenergic receptor (Ki =5 nM measured in radioligand binding assay) and selectivity over α2A (15% of displacement at 1 μM in radioligand binding assay). It is potentially suitable for fluorescence-based assays such as confocal microscopy, high content screening or fluorescence polarization.

Our CELT-145 ligand is a highly potent fluorescent antagonist developed for hA1R testing with a Ki of 160 nM in radioligand binding assay. The product comes in a 10ug vial that enables the preparation of 63ml of 100nM working solution to test AT1R. Our fluorescent antagonist is ideal for visualization in confocal microscopy and high-content system experiments. Our CELT-145 ligand is potentially suitable for other fluorescence-based assays such as HTRF.

Our potent CELT-150 VHL E3 ligase fluorescent ligand is a tracer for VHL E3 ligases binding assays, designed to perform affinity binding curves to VHL protein using TR-FRET homogenous technology. Von Hippel–Lindau protein (VHL) is the substrate recognition subunit of an E3 ligase recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a targeted protein.