Lipids & Polymers

DOTMA forms stable cationic liposomes in solution and can be used in the cell transfection of DNA RNA oligonucleotides anionic proteins and small peptides. DOTMA increased by at least 1000-fold the activity of an antisense oligonucleotide (ISIS 1570) in human umbilical vein endothelial cells.

DODMA is an ionizable lipid used for preparation of lipid nanoparticles and liposomes for delivery of RNA and DNA.

9A1P9 is a multi-tail ionizable phospholipid which promotes membrane destabilization and cargo release enhancing mRNA delivery and gene editing. Lipid nanoparticles prepared with 9A1P9 exhibited 40- to 965-fold higher in vivo mRNA delivery efficacy compared to DOPE and DSPC.

DBCO-PEG24-Maleimide is a PEG linker containing a DBCO moiety and a terminal primary maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

MAB40 is part of BBI's anti-Biotin Gold Conjugate family which include anti-Biotin antibodies or streptavidin conjugated to BBI gold nanoparticles for use in the detection of biotinylated markers. Monoclonal anti-Biotin (MAB) conjugated to 40nm colloidal gold nanoparticles can be produced in large volumes of up to 24L OD10 per batch. The antibody is a high quality monoclonal antibody produced in mouse ascites and protein G purified to give a purity of greater than 90%. It is passively coupled to citrate capped gold nanoparticles and blocked with bovine serum albumin (BSA) For customers moving away from ELISA to lateral flow, biotinylated antibodies will generate gold labelled antibody conjugates in one simple step. Generally, biotin attaches to the Fc part of the antibody, leaving the variable part free to react with the antigen and form a fully active conjugate. Suitable for use in lateral flow devices. It can utilised in a range of matrices including whole blood, serum, urine, saliva

DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Biotin-PEG5-alcohol is a biotinylation reagent containing a primary hydroxyl that can be derivatized. The PEG spacer provides greater solubility to labeled molecules compared to reagents having only hydrocarbon spacers.