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2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid is a thalidomide analog that can be useful in PROTAC research.

2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid is a thalidomide analog that can be useful in PROTAC research.

2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) is a lenalidomide analog that can be useful in PROTAC research.

Lenalidomide is used to treat multiple myeloma through the interaction with the ubiquitin E3 ligase cereblon, which leads to the degradion of the Ikaros transcription factors IKZF1 and IKZF3. This indicates that the major action of lenalidomide is to re-target the activity of an enzyme rather than block the activity of an enzyme or signaling process.

3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione has been shown to treat Diffuse large B-cell lymphoma (DLBCL) with antitumor and immunomodulatory activity.

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research.