PEG

Azido-PEG19-azide is a click chemistry reagent with two terminal azide groups. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry.

Bromoacetamido-PEG4-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide. The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

t-Boc-N-Amido-PEG10-propargyl is a propargyl linker with one side protected by Boc group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc protected amine can be deprotected under mild acidic conditions.

Amino-PEG19-amine is a PEG linker containing two amine functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

2-(Propargyl-PEG4-amido)-1,3bis(PEG1-methyl ester) is a crosslinker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.

DSPE-PEG-Mannose, MW 10,000 is a PEG polymer containing DSPE and Mannose end groups. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.

DSPE-PEG-Mannose, MW 20,000 is a PEG polymer containing DSPE and Mannose end groups. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.

3,3-Bis(N,N-dipropanoic acid) can be used in preparation of linkers, lipids, and conjugates of cytotoxic agents.

t-Boc-N-amido-PEG12-NHS ester is a PEG linker containing a Boc-protected amino group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The protected amine can be deprotected in acidic conditions.