PEG

PEG3-(Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane)-(Amino-Tri-(carboxyethoxymethyl)-methane) is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid groups can react with primary amino groups in the presence of activators (e.g. HATU) to form a stable amide bond.

m-PEG3-bromide is a PEG linker containing a terminal bromide. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

NH-bis(PEG1-acid) is a branched PEG molecule that is reactive with activated NHS esters under neutral conditions.

N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-acid) is a crosslinker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The terminal carboxylic acids can react with primary amino groups in the presence of activators (e.g. HATU) to form a stable amide bond.

PC SPDP is a photocleavable linker with a SPDP moiety. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions.

E3 Ligase ligand 1a is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 Ligase ligand 1a can be used to synthesize ARV-771, a BET PROTAC degrader.

(S,R,S)-AHPC-C4-NH2 is a E3 ligase ligand-linker conjugate that comprises the (S,R,S)-AHPC based VHL ligand and a four carbon alkane linker used for EED-Targeted PROTAC. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S,R,S)-AHPC-C6-NH2 is a E3 ligase ligand-linker conjugate that comprises the (S,R,S)-AHPC based VHL ligand and a six carbon alkane linker used for EED-Targeted PROTAC. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S,R,S)-AHPC-Me-C10-NH2 is a E3 ligase ligand-linker conjugate that couples the VHL ligand to a 10 carbon alkane linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.