PEG

(S,R,S)-AHPC-amido-C2-acid is a VHL ligand with a 2 carbon alkyl linker and terminal acid for PROTAC compounds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

(S,R,S)-AHPC-amido-C6-acid is a VHL ligand with a 6 carbon alkyl linker and terminal acid for PROTAC compounds. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

VH-298 is an E3 ligase ligand-linker conjugate that couples the VHL ligand and blocks the interaction between VHL and HIF-α, initiating a hypoxic response.

Bis-sulfone-PEG4-TCO is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. TCO enables fast click chemistry with tetrazine under mild conditions. The hydrophilic PEG spacer increases solubility in aqueous media.

DSPE-PEG-Boronate, MW 3,400 is a phospholipid PEG polymer which can form lipid bilayer in aqueous solution. Phenyl boronic acid (PBA) moiety has been most widely studied and used in construction of glucose-responsive systems for insulin delivery. Additionally, PBA materials have been used to prepare nanoparticles/micelles for delivering therapeutic agents, such as proteins, mRNA, siRNA, etc.

N-Boc-Methoxy-tris(ethylenoxy)-L-alanin has a Boc protected L-alanine residue and an methyl group. The Boc protecting group can be removed under acidic conditions.

N-DBCO-N-bis(PEG2-amide-PEG4-Acid) is a precursor of antibody drug conjugates (ADCs). It contains a DBCO group and two terminal carboxylic acid groups. DBCO group is a highly reactive cycloalkyne which is commonly used for copper-free Click Chemistry reactions. The acid groups can derivatize amine-containing molecules in the presence of activators such as EDC or HATU.

Biotin-PEG8-TCO is a biotin PEG reagent with a terminal TCO group. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule. TCO enables fast click chemistry with tetrazine under mild conditions.

Biotin-PEG12-TCO is a biotin PEG reagent with a terminal TCO group. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule. TCO enables fast click chemistry with tetrazine under mild conditions.