PEG

C18-PEG4-Azide is a hybrid linker featuring a hydrophobic C18 chain, a hydrophilic PEG4 spacer, and an azide. The azide is reactive with terminal alkynes or strained cyclooctynes such as DBCO or BCN through click chemistry.

N-(Biotin-PEG2)-N-Bis(PEG3-azide) is a branched biotinylation reagent for labeling. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. Reagent grade, for research use only.

DBCO-PEG12-para-phenylboronic acid is a click chemistry reagent with a DBCO group and a terminal Phenyl boronic acid. The DBCO can undergo copper-free Click Chemistry reactions with azides. Phenyl boronic acid (PBA) moiety has been most widely studied and used in the construction of glucose-responsive systems for insulin delivery. Additionally, PBA materials have been used to prepare nanoparticles/micelles for delivering therapeutic agents, such as proteins, siRNA, anti cancer agent, etc. The hydrophilic PEG linker increases the water solubility of the compound. Reagent grade, for research use only.

N-(alfa-Maleimidoacetoxy)succinimide is a small molecule featuring both an NHS ester and a maleimide. The NHS is easily displaced by amine nucleophiles to form amides with target molecules while maleimide is a thiol-specific covalent moiety which is used to label reduced cysteines in proteins.

Mal-amido-PEG1-C2-NHS ester is a small molecule featuring both an NHS ester and a maleimide. The NHS is easily displaced by amine nucleophiles to form amides with target molecules while maleimide is a thiol-specific covalent motif which is used to label reduced cysteines in proteins.

4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate is an aliphatic linker featuring a thiol-reactive 2-thiopyridine and an amine-reactive 4-nitrophenyl carbonate.

Mal-amido-PEG10-NHS is a PEG linker featuring both an NHS ester and a maleimide. The NHS group is easily displaced by amine nucleophiles while maleimide is a thiol-specific covalent group which is used to label reduced cysteines in proteins.

3-(4-Acetylphenyl)-2-aminopropanoic acid hydrochloride

DSPE-Polysarcosine20 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine). The DSPE, 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine, is comprised of a phosphorylethanolamine phospholipid acylated with C18:0 fatty acids. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. DSPE-Polysarcosine can be used in lipid formulas to create lipid nanoparticles (LNPs) for therapeutic applications of mRNA.