PEG

Azide-pGlu, MW 2,500 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal azide group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Azide-pGlu, MW 10,000 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal azide group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

OPSS-PGlu, MW 5,000 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal Orthopyridyl disulfide (OPSS) group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal OPSS group can selectively react with free thiol, SH, sulfhydryl or mercapto to form reversible disulfide bonds.

PLGA(1.4k)-PEG(1k)-PLGA(1.4k) is a large PEG-PLGA conjugate containing a two hydrophobic poly(lactide-co-glycolide) groups linked together by a hydrophilic PEG spacer. PLGA is often used in forming lipid nanoparticles for drug delivery, for which it is highly valued as it is also biodegradable along its ester bonds. PLGA can also be functionalized at its terminal secondary alcohols to further expand its chemical complexity.

PEI-g(10k)-PEG(5k), 10% PEG ratio is a graft copolymer of branched PEI (bPEI) which is modified with a 5 kDa mPEG along 10% of its residues. bPEI shows variable solubility in water, which is improved through the inclusion of hydrophilic PEG residues. These copolymers can be used to improve drug delivery of oligonucleotides. Altering the MW or % PEG of a PEI copolymer will alter a number of factors crucial to ADME such as size, surface charge, and stability. Finally, PEI-PEG copolymers are easily functionalized along the many primary amines in the PEI structure.

PEI-g(10k)-PEG(5k), 20% PEG ratio is a graft copolymer of branched PEI (bPEI) which is modified with a 5 kDa mPEG along 10% of its residues. bPEI shows variable solubility in water, which is improved through the inclusion of hydrophilic PEG residues. These copolymers can be used to improve drug delivery of oligonucleotides. Altering the MW or % PEG of a PEI copolymer will alter a number of factors crucial to ADME such as size, surface charge, and stability. Finally, PEI-PEG copolymers are easily functionalized along the many primary amines in the PEI structure.

PLLA(30k)-PEG(5k)-NH2 is a functional amphiphilic block copolymer (ABC) which has amine group at the end of PEG block. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc. PLA-PEG is one of the most commonly used biodegradable ABC polymers for drug delivery. Reagent grade, for research use only.

PLLA(30k)-PEG(5k)-NH2 is a functional amphiphilic block copolymer (ABC) which has amine group at the end of PEG block. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc. PLA-PEG is one of the most commonly used biodegradable ABC polymers for drug delivery. Reagent grade, for research use only.

t-Boc-N-amido-PEG-amine, MW 1,000 is a linear heterobifunctional PEG reagent with a Boc-protected amine and free amine. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc. The Boc group can be deprotected under mild acidic conditions to form the free amine. It is a useful crosslinking reagent with a PEG spacer. Reagent grade, for research use only.