PEG

Amino-PEG12-amine is a conjugation linker containing two amine (NH2) groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Reagent grade, for research use only.

t-Boc-Aminooxy-PEG7-Mal contains a Boc-protected aminooxy group and a terminal maleimide group. The maleimide group will react with a thiol group to form a covalent bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions. Reagent grade, for research use only.

Benzyl-PEG13-alcohol is a PEG linker with a benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. The benzyl group can be removed under catalytic hydrogenation conditions to give free hydroxyl for derivitazation. Reagent grade, for research use only.

N-Desthiobiotin-N-bis(PEG4-Acid) is a PEG linker containing two carboxylic acid groups and desthiobiotin, which is a modified form of biotin that binds to avidin, streptavidin and other biotin-binding protein-based affinity columns are recognized by anti-biotin antibodies. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU). Reagent grade, for research use only.

PEG3-tetrazine is an aqueous souluble PEG linker containing a terminal hydroxyl group and tetrazine group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The chemical stability of tetrazines is lower compared to methyltetrazines, but it is in acceptable range and thus can be applied for many applications. Reagent grade, for research use only.

Iberdomide is a derivative of Thalidomide and has antitumor and immunostimulatory activities because it is a potent cereblon (CRBN) E3 ligase modulator. Reagent grade, for research use only.

CC-90009 is a modulator of the E3 ligase cereblon (CRBN), binding to cereblon and leading to the induction of ubiquitination and proteasomal degradation of GSPT1. Reagent grade, for research use only.

CFT7455 is an orally active compound that degrades zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). It is an anti-cancer agent that binds with high affinity to the cereblon E3 ligase, making it useful in PROTAC development. Reagent grade, for research use only.

NVP-DKY709 is a highly potent inhibitor of IKZF2, designed for cancer research and PROTAC development. Reagent grade, for research use only.