PEG

MC-PEG2-NH2 (Legacy Tebubio ref. 282T77871). MC-PEG2-NH2 is a cleavable linker used in antibody-drug conjugate (ADC) synthesis [1].

Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (Legacy Tebubio ref. 282T77887). Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (compound 5) is a branched linker used in antibody-drug conjugate (ADC) synthesis [1].

Biotin-PEG-Thiol (MW 2000) (Legacy Tebubio ref. 282T78418). Biotin-PEG-Thiol (MW 2000) is a compound composed of biotin, polyethylene glycol and thiol, an active polymer that can be used to study nanomaterials.

Rha-PEG3-SMCC (Legacy Tebubio ref. 282T81280). Rha-PEG3-SMCC (Compound 13) serves as an ADC (antibody-drug conjugate) linkage agent with robust antitumor properties, utilizing the protein crosslinker SMCC, which is tethered through the non-cleavable linker Rha-PEG3.

PEG6-(CH2CO2H)2 (Legacy Tebubio ref. 282T8232). PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker.

Pomalidomide 4'-PEG5-amine (Legacy Tebubio ref. 282T83953). Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It is among a series of functionalized tool molecules specifically crafted for PROTAC R&D.

tri-GalNAc-PEG3-Azide (Legacy Tebubio ref. 282T83964). Tri-GalNAc-PEG3-Azide is a specialized compound designed for lysosomal targeting chimera (LYTAC) research, featuring three asialoglycoprotein receptor (ASGPR) ligands linked by a PEG3 spacer and an azide group for easy conjugation. This compound facilitates efficient internalization into hepatocytes through ASGPR-mediated endocytosis, making it a strategic tool for delivering RNA, Cas9 complexes, or other cargo specifically to liver cells. Additionally, it can be utilized to create LYTACs or to be marked with a dye for tissue imaging applications.

DSPE-PEG5000-Mal ammonium (Legacy Tebubio ref. 282T84748). DSPE-PEG-Maleimide, a compound comprised of DSPE phospholipid and maleimide, is utilized for preparing nanostructured lipid carriers, enhancing both blood circulation time and stability of encapsulated agents [1] [2]. The variant DSPE-PEG5000-Mal includes PEG5000, further contributing to its utility in drug delivery systems.

Pomalidomide 4'-PEG5-azide (Legacy Tebubio ref. 282T84902). Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].