Enzymes

Human HDAC9 , GenBank Accession No. NM_178423, a.a. 604-1066 with C-terminal His-tag, MW= 50.7 kDa, expressed in baculovirus expression system.

Lyophilized. Dialyzed.

Human LpxC, also known as UDP-3-O-N-acetylglucosamine deacetylase, GenBank Accession No. NP_253096.1, a.a. 1-305 (end), expressed in an E.coli expression system. MW = 34 kDa.

Human matrix metallopeptidase-3 (MMP3), also known as Stromelysin-1 (STMY1), GenBank Accession No. NM_002422, a.a. 18-477(end) with a Lys to Glu mutation at a.a. 45 and a C-terminal His-tag, expressed in a HEK293 cell expression system. MW=54 kDa.

Human NNMT1 also known as Nicotinamide N-Methyltransferase, GenBank Accession No. NM_006169, a.a. 1-264(full length), with C-terminal His-tag, expressed in an E. coli expression system. MW=30 kDa.

Mouse PDE1B (GenBank Accession No. NM_008800), a.a. 42-535 (end), with N-terminal GST-tag, MW= 83 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Human PDE4B3 (GenBank Accession No. NM_001037340), 2-721 (end), with N-terminal GST tag, MW=108 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.