Enzymes

Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

Human MYLIP, also known as Inducible Degrader of the LDL receptor (IDOL), GenBank Accession No. NM_013262, a.a. 2-445(end), with N-terminal His-FLAG-tag, MW=51.7 kDa, expressed in a baculovirus expression system.

Human DRAK2, (GenBank Accession No. NM_004226.3), a.a. 2-372 (end), with N-terminal GST-tag, MW = 69 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

Human DRAK2, also known as DAP kinase-related apoptosis-inducing protein kinase 2 or death-associated protein kinase-related 2 (GenBank Accession No. NM_004226.3), a.a. 2-372 (end), MW = 43 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

Human glutaminase liver isoform (liver, mitochondria), also known as GLS2, L-glutaminase, and L-glutaminase amidohydrolase, GenBank Accession No. NM_013267, a.a. 15-602, with N-terminal His-tag, MW=66 kDa, expressed in an E. coli cell expression system.

The MAT2a Inhibitor Screening Assay Kit is designed to measure MAT2A activity for screening and profiling applications. The MAT2A assay kit comes in a convenient 384-well format, with purified recombinant MAT2A enzyme, L-Methionine, ATP, MAT2A assay buffer, and Colorimetric detection reagent for 384 enzyme reactions.

The TDO Inhibitor Screening Assay Kit is designed to measure TDO enzyme inhibition. The kit comes in a convenient format, with enough reaction solution and enzyme to perform a total of 100 reactions. The TDO Inhibitor Screening Assay Kit is simple to use. Inhibitor and enzyme are added to a sample containing L-Trp substrate. After a room temperature incubation activity is measured by measuring the absorption of reaction product at λ = 320-325 nm.

The TPH1 Assay Kit is designed to measure TPH1 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple - just mix two solutions, incubate, add quenching solution, and measure the fluorescence.

The TPH2 Assay Kit is designed to measure TPH2 enzyme inhibition in a 96 reaction format. This fluorescence-based assay kit is especially suitable for high throughput screening applications. The procedure is quick, straightforward, and simple -? just mix two solutions, incubate, add quenching solution, and measure the fluorescence.