Extra Cellular Matrix

NativeCoat™ Skin ECM Surface Coating is used to functionalize cell culture surfaces with skin-specific extracellular matrix proteins. Coating with tissue-specific biochemical composition of the native cell microenvironemnt results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways.

TissueSpec® Intestine Hydrogel is an extracellular matrix product comprised of collagens and other ECM molecules of intestine-specific origin. TissueSpec® hydrogels provide intestine cells a soft, physiologic substrate for 3D cell culture to enhance cell function and cell-cell interactions.The hydrogel format is highly versatile and can be used to culture cells on thin gels or embeed cells or organoids within thick gels.

xeno-free hydrogel system for three-dimensional (3D) cultures of mesenchymal stem cells (MSCs). For hydrogel-cell beads for MSC scale-up. No more microcarriers needed. . VitroGel MSC is ready-to-use with an optimized formulation that fully supports the rapid expansion of MSCs. Cells directly thawed from liquid nitrogen or passaged from 2D culture vessels can be immediately mixed with the hydrogel solution for 3D culture or hydrogel-cell bead generation. This hydrogel system is compatible with most MSC culture media and tissue culture vessels. By using the VitroGel Cell Recovery Solution, the cell harvesting after 3D culture is simple and effective.

NativeCoat™ Lung ECM Surface Coating is used to functionalize cell culture surfaces with lung-specific extracellular matrix proteins. Coating with tissue-specific biochemical composition of the native cell microenvironemnt results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways.

NativeCoat™ Liver ECM Surface Coating is used to functionalize cell culture surfaces with liver-specific extracellular matrix proteins. Coating with tissue-specific biochemical composition of the native cell microenvironemnt results in increased cell attachment, viability and proliferation as well as enhanced function and activation of signaling pathways.

Xeno-free hydrogel for organoid formation Supports a wide range of organoids from patient-derived samples, stem cells, tissues, co-culture and PDX resources Operation protocol at room temperature, automation-friendly Easy 20-minute cell harvesting (enzyme-free) VitroGel® ORGANOID (1-4) are xeno-free (animal origin-free) hydrogels that support the growth of patient-derived organoids or organoids developed from pluripotent stem cells (PSCs), co-culture, and PDX model. VitroGel ORGANOID hydrogels are ready to use at room temperature and have a neutral pH, transparent, permeable, and compatible with different imaging systems. The solution transforms into a hydrogel matrix by simply mixing with the cell culture medium. VitroGel ORGANOID hydrogels are good for both 3D cell culture and 2D hydrogel coating applications.

TissueSpec® Heart ECM Hydrogel is an extracellular matrix product comprised of collagens and other ECM molecules of heart-specific origin. TissueSpec® hydrogels provide heart cells a soft, physiologic substrate for 3D cell culture to enhance cell function and cell-cell interactions.The hydrogel format is highly versatile and can be used to culture cells on thin gels or embeed cells and organoids within thick gels.

In order to enable physiologically-relevant studies of metastatic tumor colonization or dormancy as well as accelerate drug development, Xylyx Bio offers the IN SITE™ Metastasis Kit that incorporates bone, liver, and lung extracellular matrices to provide tissue-specific composition and key extracellular features of the metastatic secondary site microenvironments. IN SITE™ Metastasis Kit provides greater control over the tumor microenvironment in vitro and represents the best platform to study carcinogenesis, migration, and metastasis or test therapeutic interventions in native ECM environments.

xeno-free hydrogel system for organoid culture. VitroGel® ORGANOID  are xeno-free (animal origin-free) hydrogels that support the growth of patient-derived organoids or organoids developed from pluripotent stem cells (PSCs).