Lipids & Polymers

1,2-Epoxyoctadecane is a chemical reagent featuring an epoxy group on a C8 chain. The epoxy group undergoes ring opening in the presence of nucleophiles to form a branched secondary alcohol. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

endo-BCN-OH is a click chemistry handle which readily reacts with azides. The primary alcohol allows it to be ligated to other linkers.

Diazo-PEG3-methyltetrazine is a TCO reactive reagent with a PEG3 linker for improved water-solubilitiy and a diazo group for efficient release of captured molecules.

4-(N-methyl-N-phenylamino)butanoic NHS ester is a short linker featuring a methylaniline and an NHS ester. The NHS is a good leaving group which is easily displaced by nucleophiles while methylaniline is a highly electron-dense heterocycle with a variety of chemical uses.

m-PEG-bromide, MW 5,000 is a large PEG molecule containing a methoxy and a bromide. The methoxy group caps one end of the molecule to allow the PEGylation of a target molecule to proceed on only one end of this molecule at the terminal bromide. PEG linkers with high molecular weights such as this one are frequently employed in developing PEG-lipid conjugates such as the ones used to create lipid nanoparticles for drug delivery.

N-Methylaniline-PEG3-TCO is a short PEG linker featuring a methylaniline and a TCO group. TCO is a click chemistry handle which readily reacts with tetrazine-containing compounds while methylaniline is a highly electron-dense heterocycle with a variety of chemical applications.

N-Methylaniline-PEG3-methyltetrazine is a short PEG linker featuring a methylaniline and a methyltetrazine group. Methyltetrazine is a click chemistry motif which readily reacts with TCO-containing compounds while methylaniline is a highly electron-dense heterocycle with a variety of applications.

t-Boc-Aminooxy-PEG7-azide is a short bifunctional PEG linker featuring an azide and a Boc-protected amine. Azides readily react with alkynes through click chemistry, while the Boc protecting group can be removed using strong acid.

Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. This multi-ionizable compound can be used in developing lipid nanoparticles.