Lipids & Polymers

Boc-PEG4-C2-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].

Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1].

m-PEG17-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(S,R,S)-AHPC-PEG2-acid is a PEG-based linker used in PROTACs, connecting two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

Phosphatidylcholine (PC) Lipid Microparticles, pHrodoTM Red are beads with attached phosphatidylcholine and pHrodoTM Red. The PC headgroups are exposed and available for biological interactions. PC is primarily an extracellular phospholipid of cell membranes and is a key structural lipid. This product is intended as a negative control when using PS lipid microparticles in apoptosis or in phagocytosis studies. pHrodo is a trademark of ThermoFisher Scientific.

Human CD3/CD28 ActiveBeads™ induce T cell activation in enriched T cells or PBMCs.

His tag (C terminus) agarose beads is based on anti-His tag covalently coupled to the surface of agarose beads.

GST agarose beads is based on anti-GST covalently coupled to the surface of agarose beads.