Lipids

BODIPY TMR PI(4 5)P2 (BODIPY TMR Phosphatidylinositol 4 5-bisphosphate) is a water soluble analog of PI(4 5)P2 (PIP2) labeled with the orange fluorophore Bodipy®-TMR at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.Bulk discounts available please email echelon@echelon-inc.com for information. Powered by Bioz See more details on Bioz

The Bodipy Labeled PIP Sample Pack contains 10ug of all eight Bodipy FL-labeled PIPs. These water soluble PI analogs are labeled with Bodipy®-FL at the sn-1 position.Sample pack contains:BODIPY® FL PhosphatidylinositolBODIPY® FL Phosphatidylinositol 3-PhosphateBODIPY® FL Phosphatidylinositol 4-PhosphateBODIPY® FL Phosphatidylinositol 5-PhosphateBODIPY® FL Phosphatidylinositol 3 4-BisphosphateBODIPY® FL Phosphatidylinositol 3 5-BisphosphateBODIPY® FL Phosphatidylinositol 4 5-BisphosphateBODIPY® FL Phosphatidylinositol 3 4 5-Trisphosphate

1 2-Dilauroyl-sn-glycerol is a diacylglycerol (DAG) involved in phospholipid metabolism and is a substrate of diacylglycerol kinase. 1 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion. Powered by Bioz See more details on Bioz

1 2-Diacylglycerols (DAGs) are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion. Powered by Bioz See more details on Bioz

1 2-Diacylglycerols (DAGs) are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion. Powered by Bioz See more details on Bioz

1 2-Diacylglycerols (DAGs) are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion. Powered by Bioz See more details on Bioz

1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions respectively. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol is a potent activator of PKCα PKCε and PKCδ and also competitively binds to the Ras activator RasGRP. 1 2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4 5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC) which is a key regulator of signal transduction cellular regulation and tumor promotion.References1) Lapetina E.G. Reep B. Ganong B.R. & Bell R.M. (1985) "Exogenous sn-1 2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets" J. Biol. Chem. 260 1358-1361.2) Ganong B.R. Loomis C.R. Hannun Y.A. & Bell R.M. (1986) "Specificity and Mechanism of Protein Kinase C Activation by sn-1 2-diacylglycerols" Proc. Na

Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPARγ. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.References1. P.S. Baker et al “Fatty Acid Transduction of Nitric Oxide signaling” Journal of Biological Chemistry 2005 280 42464-42475;2. F.J. Schopfer et al “Covalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acid” Journal of Biological Chemistry 2010 285 12321-12333.

Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. LPA Biotin is labeled at the sn-1 position.