DNA & Clones

DNA was prepared from cell line WM983BBR. WM983BBR is a human metastatic melanoma cell line that displays a mesenchymal morphology. The WM983BBR cell line contains the BRAF V600E mutation that causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation.  WM983BBR is wild type for PTEN, N-ras, c-KIT, and CDK4. This cell line was derived from the same patient as the cell lines WM983A, WM983B, and WM983C. The WM983BBR cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM983BBR. WM983BBR is a human metastatic melanoma cell line that displays a mesenchymal morphology. The WM983BBR cell line contains the BRAF V600E mutation that causes increased signaling via the extracellular signal-regulated MAPK/ERK kinase pathways to enhance proliferation.  WM983BBR is wild type for PTEN, N-ras, c-KIT, and CDK4. This cell line was derived from the same patient as the cell lines WM983A, WM983B, and WM983C. The WM983BBR cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM983C. WM983C is a metastatic human melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type PTEN, N-RAS, c-KIT, and CDK4 genes. WM983 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM983C. WM983C is a metastatic human melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type PTEN, N-RAS, c-KIT, and CDK4 genes. WM983 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM983C. WM983C is a metastatic human melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type PTEN, N-RAS, c-KIT, and CDK4 genes. WM983 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM989. WM989 is a melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type N-RAS, c-KIT, and CDK4 genes. WM989 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM989. WM989 is a melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type N-RAS, c-KIT, and CDK4 genes. WM989 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM989. WM989 is a melanoma cell line. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line expresses wild type N-RAS, c-KIT, and CDK4 genes. WM989 cells produce xenograft tumors when injected into immunocompromised mice.