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Thalidezine (Legacy Tebubio ref. 282TN6069). Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death, it can inhibit the growth of mouse L1210 cells in vitro. Thalidezine possesses antimicrobial activity against Mycobacterium smegmatis at concentrations of 100 microgram/ml or less.