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Chemicals & Small Molecules

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    Results for Chemicals & Small Molecules ( 89587 )

      • SC-57461A

        Ref: T21696
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg
        From: DKK300.00

        SC-57461A (Legacy Tebubio ref. 282T21696). SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.

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      • Sp-Cyclic AMPS (sodium salt)

        Ref: T21697
        Sizes: 1 mg, 5 mg
        From: DKK1,448.00

        Sp-Cyclic AMPS (sodium salt) (Legacy Tebubio ref. 282T21697). Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].

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      • VKGILS-NH2 Acetate

        Ref: T21699L
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK248.00

        VKGILS-NH2 Acetate (Legacy Tebubio ref. 282T21699L). VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.

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      • SKF-96365 hydrochloride

        Ref: T2170
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: DKK450.00

        SKF-96365 hydrochloride (Legacy Tebubio ref. 282T2170). SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.

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      • NOS-IN-1 

        Ref: T21700
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: DKK503.00

        NOS-IN-1  (Legacy Tebubio ref. 282T21700). NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectively.

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      • 4-Chlorophenylguanidine hydrochloride

        Ref: T21703
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: DKK345.00

        4-Chlorophenylguanidine hydrochloride (Legacy Tebubio ref. 282T21703). 4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase.

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      • 5-fluoro 203

        Ref: T21704
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK293.00

        5-fluoro 203 (Legacy Tebubio ref. 282T21704). 5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.

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      • 8-CPT-Cyclic AMP (sodium salt)

        Ref: T21705
        Sizes: 1 mg, 5 mg, 10 mg
        From: DKK998.00

        8-CPT-Cyclic AMP (sodium salt) (Legacy Tebubio ref. 282T21705). 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) and a potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an inhibitory concentration (IC50) of 0.9 μM. It also inhibits PDE III and PDE IV while significantly activating Epac, demonstrating diverse pharmacological activities [1] [2].

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      • Angiotensin 1/2 + A (2 - 8) Acetate

        Ref: T21708L
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK338.00

        Angiotensin 1/2 + A (2 - 8) Acetate (Legacy Tebubio ref. 282T21708L). Angiotensin 1/2 + A (2 - 8) Acetate is a Vasoconstrictor.

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