Chemicals & Small Molecules

Cyanine 3.5 (Cy3.5 NHS ester) chloride, a red fluorescent dye and reactive Cy3.5 fluorophore analog, is utilized for the labeling of amino groups in peptides, proteins, and oligonucleotides. It exhibits an excitation wavelength (λ ex) of 591 nm and an emission wavelength (λ em) of 604 nm. [1] [2]

DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects, inhibits cell proliferation and induces the expression of Krüppel-like Factor 4 (KLF4) and p21 in human colon cancer cells, inhibits Notch signaling, and can be used in the study of renal tubular adenomas.

ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].

MitoTracker Orange CMTMRos, a fluorescent dye that labels mitochondria in live cells by utilizing the mitochondrial membrane potential (Ex/Em: 551/576 nm) [1].

MK-8527, an HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI), exhibits a similar inhibitory mechanism to ISL [1].

Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.

NIR-797-isothiocyanate is a versatile dye employed extensively across various scientific and industrial sectors. As a critical tool in biological experiments, this dye enables the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, examination of tissue pathology, and monitoring of microorganisms. Its applications extend from fundamental research to a broad spectrum of clinical diagnostics. Additionally, NIR-797-isothiocyanate finds usage in traditional industries like textile dyeing and in innovative areas including functional textile processing, food coloring, and dye-sensitized solar cells.

NTPO trisodium induces DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are mitigated by base excision repair (BER) but not by nucleotide excision repair (NER) [1].

Rose bengal lactone (C.I. Solvent Red 141) is a rose bengal lactone stain commonly used to stain the nuclei of plant and animal cells.