Chemicals & Small Molecules

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is employed for labeling proteins on the external leaflet of intact exosomes and features an extended spacer arm between the biotin and the amine-reactive linker. This elongated linker is designed to mitigate steric hindrance, thereby enhancing labeling efficiency on the densely populated exosome surface [1] [2].

TI17 is a selective TRIP13 inhibitor with anticancer activity that inhibits the proliferation of multiple myeloma (MM) cells and induces cycle arrest and apoptosis in MM cells.

Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.

Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.

PTPN2-IN-1 (compound 4) acts as a potent inhibitor of PTPN2, demonstrating an IC 50 of less than or equal to 5μM. It effectively inhibits the cell growth of B16F10.

Linolenyl alcohol ((9Z,12Z,15Z)-Octadeca-9,12,15-trien-1-ol) has antimicrobial activity and inhibits the growth of Gram-positive bacteria in vitro.

Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) acts as an inhibitor of both HIV-1 integrase (IN) and HIV-1 reverse transcriptase ribonuclease H (RT RNase H), exhibiting IC50 values of 6.32 µM and 5.9 µM, respectively.

Potassium ionophore III (BME-44) serves as a highly lipophilic, selective carrier for potassium ions, demonstrating pronounced selectivity over sodium and ammonium ions.

VCPIP1-IN-1 is a VCPIP1 inhibitor that is used in cancer research.