Results for Chemicals & Small Molecules ( 98737 )
- From: DKK3,825.00
ATTO488-Charybdotoxin is a fluorescent version of Charybdotoxin. Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+ activated K+ channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocks KCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) and Kv1.6 (IC50 2 nM) channels. ATTO488: λex 500nm , λem 520nm
- From: DKK3,938.00
DBCO-S-S-NHS ester functions as a cleavable reagent containing NHS ester which can directly and efficiently react with amine-bearing molecules and DBCO which participates in copper-free Click Chemistry with azides. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME, and TCEP.