Chemicals & Small Molecules

OTX-015 is a potent new BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.

PF-2545920 is an inhibitor of phosphodiesterase 10A (PDE10A) with IC50 value of 0.37nM

PF-2545920 is an inhibitor of phosphodiesterase 10A (PDE10A) with IC50 value of 0.37nM

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 µM.

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 µM.

A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.

A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.

Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol activates sirtuin subtype 1 (SIRT-1). SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation.

RGFP966 is specific for HDAC3, with an IC50 of 0.08 µM and no effective inhibition of any other HDAC at concentrations up to 15 µM.