Chemicals & Small Molecules

EPZ015666 is a potent, selective, competitive PRMT5 inhibitor (IC50 = 22 nM). EPZ015666 exhibits >10,000-fold specificity for PRMT5 vs. other methyltransferases. EPZ015666 blocks the association of PRMT5 with methylosome protein 50 (WDR77), which is necessary to form an active methyltransferase complex. Treatment of MCL cell lines with nM concentrations of EPZ015666 leads to inhibition of SmD3 methylation and cell death."

Guanosine 5'-triphosphate sodium salt hydrate (GTP) functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways.

Guanosine 5'-triphosphate sodium salt hydrate (GTP) functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways.

3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

3-aminobenzamide is a novel, potent inhibitor of PARP. Also acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.

SiR-NHS ester is the N-hyroxysuccinimidyl ester of SiR. This amine reactive probe enables the preparation of custom SiR probes. SiR-NHS ester can be coupled to any amine bearing ligand: antibody, drug, protein or nucleic acid. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.

SiR-NHS ester is the N-hyroxysuccinimidyl ester of SiR. This amine reactive probe enables the preparation of custom SiR probes. SiR-NHS ester can be coupled to any amine bearing ligand: antibody, drug, protein or nucleic acid. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.

SiR-COOH is the carboxylic acid form of SiR. The free carboxylic acid can be activated with various coupling agents to allow the preparation of custom SiR probes. SiR-COOH can be coupled to a large variety of ligands such as antibodies, drugs, proteins or nucleic acids. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.

SiR-COOH is the carboxylic acid form of SiR. The free carboxylic acid can be activated with various coupling agents to allow the preparation of custom SiR probes. SiR-COOH can be coupled to a large variety of ligands such as antibodies, drugs, proteins or nucleic acids. SiR is compatible with GFP and/or m-cherry fluorescent proteins. It can be imaged with standard Cy5 filtersets.