Chemicals & Small Molecules

Stemolecule CHIR99021 (2 mg)

*High selectivity to lipid droplet (low background) *4 color available (blue, green, red, and deep red) *High intracellular retentivity *Applicable to both live and fixed cells

Polyethylene glycol Water-soluble and non-toxic polymer. Increases solubility of therapeutic proteins and peptides.

Stemolecule LDN-193189 (2 mg)

against mycobacteria

Aminoglycoside antibiotic

Activity: Tankyrase inhibitor, Cardiomyogenesis inducer . Function/Pharmacology: Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes wnt signaling via stimulation of ß-catenin degradation and stabilization of actin.1 Robustly induces cardiomyogenesis of stem cells.2 Cell Permeable Chemical Name: 2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol

Activity: ALK4,5 and 7 inhibitor . Function/Pharmacology: Potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM)1,2. Inhibits TGFβ-induced proliferation of human osteosarcoma cells3. Ehances growth and integrity of embryonic stem cell-derived endothelial cells4. A frequently used agent employed in numerous stem cell differentiation protocols5. Cell permeable. Chemical Name: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Activity: Autophagosome inhibitor . Function/Pharmacology: Inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity3. Enhances celastrol-induced apoptosis in human pancreatic cancer cells4. Chemical Name: 3-Methyl-3H-purin-6-amine