Chemicals & Small Molecules

-SulfoBiotics- HSip-1 is a novel fluorescent probe to detect H2S selectively and it emits strong green fluorescence when it reacts with H2S.

-SulfoBiotics-HSip-1 DA is cell membrane permeable and it enables fluorescent imaging of intracellular H2S.

*A Newly Fluorogenic β-galactosidase Detection Probe *Applicable for Living Cell and Tissues *Detect β-galactosidase at Single-Cell Resolution *Quantify SA-βgal in Cellular Senescence Assay

TPEN is a highly selective chelator of transition metal cations because the pyridine groups act as soft electron donators. TPEN is thus utilized for masking transition metal cations in fluorescent calcium monitoring.

This is a laboratory product for research use only. Not for personal consumption. It will not be effective and is dangerous for personal use.

This is a laboratory product for research use only. Not for personal consumption. It will not be effective and is dangerous for personal use.

Activity: Mitochondrial import inhibitor . Function/Pharmacology: Inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM). MitoBloCK-6 elucidated an unexpected role for Erv1 in the carrier import pathway, namely transferring substrates from the translocase of the outer membrane complex into the small Tim complexes. It impaired cardiac development in zebrafish embryos and induced apoptosis via the release of cytochrome c in human embryonic stem cells but not differentiated cells1. Chemical Name: 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol

Activity: Disrupts actin filaments . Function/Pharmacology: Potent inhibitor of actin polymerization which also causes the disruption of actin filaments. More potent that cytochalasin B (10-fold) and does not inhibit monosaccharide transport across cell membranes. Disruption of actin microfilaments leads to activation of p53. Cell permeable Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

Activity: Microtubule stabilizing agent . Function/Pharmacology: Taxol is a clinically useful cancer chemotherapeutic agent for the treatment of breast, non-small cell lung and ovarian cancer.1 It acts as a promoter of tubulin polymerization and stabilizes microtubules in vitro and in vivo resulting in arrest of cells in the G2 and M phase of the cell cycle.2