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Macluraxanthone (Legacy Tebubio ref. 282TN5912). Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the polarization of M1-like pro-inflammatory macrophages by increasing the percentage of macrophages expressing CD86 while decreasing their expression of CD14, CD11b and CD80. Macluraxanthone significantly reduced the production of TNF-α and IL-10 cytokines in the presence of the pro-inflammatory stimulant lipopolysaccharide.