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Results for Chemicals & Small Molecules ( 97555 )
- From: DKK6,945.00
TAT-cyclo-CLLFVY (Legacy Tebubio ref. 282TP2046). Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.