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Chemicals & Small Molecules

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    Results for Chemicals & Small Molecules ( 97557 )

      • Doxepin hydrochloride

        Ref: T1540
        Sizes: 1 g, 500 mg, 10 g, 5 g, 1 mL * 10 mM (in DMSO)
        From: DKK360.00

        Doxepin hydrochloride (Legacy Tebubio ref. 282T1540). Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

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      • GNE-272

        Ref: T15400
        Sizes: 25 mg, 100 mg, 50 mg, 2 mg
        From: DKK915.00

        GNE-272 (Legacy Tebubio ref. 282T15400). GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.

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      • GNE-371

        Ref: T15401
        Sizes: 1 mg
        From: DKK2,550.00

        GNE-371 (Legacy Tebubio ref. 282T15401). GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain.

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      • GNE-618

        Ref: T15403
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 1 mL * 10 mM (in DMSO)
        From: DKK1,523.00

        GNE-618 (Legacy Tebubio ref. 282T15403). GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.

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      • GNE-6468

        Ref: T15404
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 1 mL * 10 mM (in DMSO)
        From: DKK3,023.00

        GNE-6468 (Legacy Tebubio ref. 282T15404). GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).

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      • GNE-781

        Ref: T15405
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: DKK1,418.00

        GNE-781 (Legacy Tebubio ref. 282T15405). GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).

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      • GNE-955

        Ref: T15406
        Sizes: 25 mg, 100 mg, 50 mg
        From: DKK16,770.00

        GNE-955 (Legacy Tebubio ref. 282T15406). GNE-955 is a potent and orally active inhibitor of pan Pim kinase, with inhibition constants (Kis) of 0.018 nM, 0.11 nM, and 0.08 nM for Pim1, Pim2, and Pim3, respectively.

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      • GNE-0723

        Ref: T15407
        Sizes: 25 mg, 100 mg, 50 mg
        From: DKK18,053.00

        GNE-0723 (Legacy Tebubio ref. 282T15407). GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively).

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      • GNE 5729

        Ref: T15408
        Sizes: 25 mg, 100 mg, 50 mg
        From: DKK12,945.00

        GNE 5729 (Legacy Tebubio ref. 282T15408). GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively).

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