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Chemicals & Small Molecules

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    Results for Chemicals & Small Molecules ( 97587 )

      • SKF-96365 hydrochloride

        Ref: T2170
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: DKK450.00

        SKF-96365 hydrochloride (Legacy Tebubio ref. 282T2170). SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.

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      • NOS-IN-1 

        Ref: T21700
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: DKK503.00

        NOS-IN-1  (Legacy Tebubio ref. 282T21700). NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectively.

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      • 4-Chlorophenylguanidine hydrochloride

        Ref: T21703
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 1 mL * 10 mM (in DMSO)
        From: DKK345.00

        4-Chlorophenylguanidine hydrochloride (Legacy Tebubio ref. 282T21703). 4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase.

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      • 5-fluoro 203

        Ref: T21704
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK293.00

        5-fluoro 203 (Legacy Tebubio ref. 282T21704). 5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK.

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      • 8-CPT-Cyclic AMP (sodium salt)

        Ref: T21705
        Sizes: 1 mg, 5 mg, 10 mg
        From: DKK998.00

        8-CPT-Cyclic AMP (sodium salt) (Legacy Tebubio ref. 282T21705). 8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA) and a potent inhibitor of cyclic GMP-specific phosphodiesterase (PDE VA) with an inhibitory concentration (IC50) of 0.9 μM. It also inhibits PDE III and PDE IV while significantly activating Epac, demonstrating diverse pharmacological activities [1] [2].

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      • Angiotensin 1/2 + A (2 - 8) Acetate

        Ref: T21708L
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK338.00

        Angiotensin 1/2 + A (2 - 8) Acetate (Legacy Tebubio ref. 282T21708L). Angiotensin 1/2 + A (2 - 8) Acetate is a Vasoconstrictor.

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      • SEW​2871

        Ref: T2171
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)
        From: DKK413.00

        SEW​2871 (Legacy Tebubio ref. 282T2171). SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.

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      • BAY 41-8543

        Ref: T21712
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 2 mg
        From: DKK278.00

        BAY 41-8543 (Legacy Tebubio ref. 282T21712). BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).

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      • BMS453

        Ref: T21714
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)
        From: DKK495.00

        BMS453 (Legacy Tebubio ref. 282T21714). BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

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