Results for Chemicals & Small Molecules ( 97587 )
- From: DKK668.00
LT175 (Legacy Tebubio ref. 282T21812). LT175, a dual PPARα/γ ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARγ with EC50 values of 0.22 μm for hPPARα, 0.26 μm for mPPARα, and 0.48 μm for hPPARγ. LT175 specifically interacts with PPARγ, influencing the recruitment of coregulators, such as the cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), within a hydrophobic region known as the diphenyl pocket [1].
- From: DKK2,258.00
ONO 4817 (Legacy Tebubio ref. 282T21814). ONO-4817 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor that potentially mitigates atherosclerotic neointimal proliferation and atheromatous plaque progression by suppressing matrix metalloproteinases (MMPs). It effectively reduces the development of aortic intimal hyperplasia in experimental hyperlipidemic rabbits [1].