Chemicals & Small Molecules

Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative that is a major immunogen for sulfonamide hypersensitivity reactions, is cytotoxic, and is immunogenic in rodents.

Tri(2-butoxyethyl) phosphate (Phosflex T-bep), a plastic plasticizer and flame retardant, is an organophosphate derived from milk powder.

Protein acetylation is a common posttranslational modification that plays a crucial role in regulating biological processes such as gene expression, cell proliferation, and metabolic regulation. The acetylation level of proteins within cells is regulated by both acetyltransferases and deacetylases. Deacetylase inhibitors can effectively prevent the loss of acetylation modifications to increase the acetylation level. TargetMol deacetylase inhibitor cocktail consists of four components that effectively inhibit the activity of various deacetylases and maintain protein acetylation status, including reversible inhibitors for Class I/II deacetylases such as Trichostatin A and Sodium Butyrate, a reversible inhibitor for Class III deacetylases (sirtuins, SIRTs) like Nicotinamide, and a selective reversible inhibitor for SIRT1, known as EX-527. To enhance the detection of protein acetylation level, deacetylase inhibitor cocktail can be added to cell culture medium for a certain incubation perio

Penicillin-streptomycin solution, also known as Pen-Strep, is the most commonly used combined antibiotic solution against both gram-positive and gram-negative bacteria. Penicillin can directly interfere with the synthesis of bacterial cell wall and indirectly alter the cell wall by triggering enzymatic reactions. Streptomycin can bind to the 30S subunit of the bacterial ribosome, and inhibit the synthesis of bacterial protein, ultimately leading to the death of susceptible bacteria. The solution is used to supplement cell culture media to control bacterial contamination. TargetMol's penicillin streptomycin solution (100x) is a sterile, filtered and ready-to-use antibiotic solution for cell culture. This solution contains 10,000 units/mL of penicillin and 10 mg/mL of streptomycin, prepared in 0.9% NaCI. It is recommended for use in cell culture application at 100 units/mL of penicillin and 0.1 mg/mL of streptomycin. Dilute the product 100-fold for use.

Penicillin-streptomycin-amphotericin B solution, is a commonly used solution to reduce bacterial and fungal contamination in cell culture media. Penicillin can directly interfere with the synthesis of bacterial cell wall and indirectly alter the cell wall by triggering enzymatic reactions. Streptomycin can bind to the 30S subunit of the bacterial ribosomal and inhibit the synthesis of bacterial protein, ultimately leading to the death of susceptible bacteria. The combination of penicillin and streptomycin exhibits effective antibacterial activity against both gram-positive and gram-negative bacteria. Amphotericin B exerts its antifungal effect by binding to ergosterol on the bacterial cell membrane, which will damage membrane, lead to the increase of permeability, leakage of intracellular substances and the disruption of normal metabolism. TargetMol's penicillin-streptomycin-amphotericin B solution (100×) is a sterile, filtered and ready-to-use solution for cell culture. This solution

Gentamicin solution, is a broad-spectrum aminoglycoside antibiotic that remains stable under heat and pH variations. The solution is effective against a wide range of Gram-negative and Gram-positive bacteria and is commonly used to prevent the contamination of cell cultures by bacteria. Gentamicin exerts its antibactericidal effect by irreversibly binding to the 30S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis and disrupting the integrity of the bacterial cell membrane. TargetMol's gentamicin solution is a sterile, filtered and ready-to-use solution for cell culture, containing 10 mg/mL of gentamicin sulfate. It is recommended for use in cell culture application at 0.5-50 μg/mL of gentamicin. Dilute the solution as experimental needs.

Amphotericin B solution is a broad-spectrum polyene antifungal antibiotic which is unstable at room temperature and susceptible to degradation by light, heat, and acid. The solution exerts its strongest antifungal activity at pH 6.0 to 7.5. Amphotericin B binds to ergosterol on the fungal cell membrane, which will damage membrane, increase permeability, leak intracellular substances and disrupt normal metabolism. As bacterial cell membranes do not contain ergosterol, amphotericin B is ineffective against bacteria. TargetMol's amphotericin B solution is a sterile, filtered and ready-to-use solution for cell culture, containing 250 μg/mL of amphotericin B. It is recommended for use in cell culture application at 0.25-2.5 μg/mL of amphotericin B. Dilute the solution as experimental needs.

The production and breakdown of intracellular proteins is in dynamic equilibrium under stable environmental conditions and when proteins are extracted from cells and tissues in vitro, crude cell extracts contain many endogenous enzymes that are capable of degrading the target proteins, e.g. phosphatases and proteases. These enzymes are released from the cells or activated, leading to the breakdown of the target protein and affecting the results of the analysis. To avoid this, one way to increase the yield of target proteins is to incorporate inhibitors of the relevant enzymes. TargetMol Mass Spectrometry-Compatible Protease Inhibitor Cocktail has a solvent of ddH2O and consists of four components including Aprotinin, Bestatin, E-64 and Leupeptin, which have broad specificity for serine and cysteine proteases and aminopeptidases, and no EDTA. This product is free of AEBSF, which avoids the potential for peak drift in mass spectra. This product does not contain AEBSF, thus avoiding the p

The production and breakdown of intracellular proteins is in dynamic equilibrium under stable environmental conditions and when proteins are extracted from cells and tissues in vitro, crude cell extracts contain many endogenous enzymes that are capable of degrading the target proteins, e.g. phosphatases and proteases. These enzymes are released from the cells or are activated, leading to the breakdown of the target protein and affecting the results of the analysis. Therefore, adding appropriate inhibitors of proteases, phosphatases and other enzymes to the extracts is an effective way to prevent protein degradation and de-modification. TargetMol Protease Phosphatase Inhibitor Cocktail is a mixture of 5 protease inhibitors and 4 phosphatase inhibitors in ddH2O, which can efficiently inhibit a wide range of proteases including serine, cysteine proteases, and aminopeptidases, as well as a wide range of phosphatases including acid, alkaline, and serine/threonine phosphatases in protein ext