Chemicals & Small Molecules

Nipocalimab (M281) is a fully humanized anti-FcRn monoclonal antibody that can be used to study systemic myasthenia gravis and rheumatoid arthritis.

Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with potential antitumor activity and can be used to study metastatic pancreatic cancer and melanoma.

Foravirumab (CR4098) is a monoclonal antibody targeting rabies virus glycoprotein (RABV-G) for the study of infectious diseases such as rabies.

WL47 TFA is a selective small molecule caveolin-1 oligomer disruptor that disrupts CAV1 oligomers.

IGF2BP1-IN-1 (Compound A11), an inhibitor of IGF2BP1, impedes the associated downstream signaling and demonstrates a high affinity for the IGF2BP1 protein with a dissociation constant (K D) of 2.88 nM. The compound effectively halts the proliferation of cancer cells, as evidenced by an IC50 of 9 nM for A549 cells and 34 nM for HCT116 cells, while also inducing apoptosis in these cells. Moreover, IGF2BP1-IN-1 has been shown to inhibit tumor growth in an A549 xenograft mouse model [1].

Abaecin acetate is a proline-enriched cationic peptide with broad-spectrum antimicrobial activity derived from the honeybee Apis mellifera.Abaecin acetate inhibits the growth of Escherichia coli in vitro.

Dectrekumab (QAX576) is a humanized monoclonal antibody targeting IL-13 that reduces the number of eosinophils in the epithelium of patients with eosinophilic esophagitis (EoE), ameliorates transcriptional dysregulation associated with esophageal disease, and is indicated for use in the study of immune system disorders.

Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the intracellular internalization and degradation of EGFR by promoting cross-linking of EGFR on the cell surface.

Iladatuzumab (MCDS0593A) is a monoclonal antibody targeting CD79B and is a naked antibody to the ADC compound Iladatuzumab vedotin, which has potential anticancer activity for the study of B-cell non-Hodgkin's lymphoma (B-NHL).