Chemicals & Small Molecules

N-(Mal-PEG2-carbonyl)-N-bis(PEG4-t-butyl ester) is a branched PEG linker possessing two t-butyl groups and a maleimide group; reactive toward thiol groups.

NHS ester-PEG4-Val-Cit-PAB-MMAE can be used in antibody drug conjugation. It has a PEG12 chain, a protease-sensitive Val-Cit dipeptide, a PAB linker and an MMAE payload.

mPEG-CH2CH2CH2-NH2, MW 2,000 is a polyPEG reagent with a 2k PEG polymer and terminal amine that is a versatile substrate which can be used to build a wide variety of bonds.

Fmoc-ala-ala-asn(trt)-pab is a protected tripeptide linker used for ADC conjugation. It contains a cleavable Ala-Ala-Asn peptide sequence. Reagent grade, for research purpose.

Fmoc-Ala-Ala-Asn(Trt)-OH is a tripeptide precursor serving as a useful component in the creation of antibody drug conjugates (ADCs).

Fmoc-Ala-Ala-Asn-PABC-PNP is a unique cleavable peptide linker. PNP group is a good leaving group when reacting with amine-bearing payload.

TRAP-6 (PAR-1 agonist peptide) is a peptide fragment that selectively activates protease-activated receptor 1 (PAR1). It functions by activating human platelets through the thrombin receptor, without affecting PAR4.

Ac-DEVD-pNA, a chromophore featuring para-nitroaniline, serves as a peptide linker cleaved by caspases. In the process of apoptosis, caspase-3 becomes activated and selectively cleaves various substrates, such as poly(ADP-ribose) polymerase, specifically recognizing the DEVD amino acid sequence.

Extracellular death factor (EDF) is a linear pentapeptide that initiates the cell death pathway in specific communicating cells. In bacteria, programmed cell death is regulated through quorum sensing, a cell-to-cell communication system. EDF is sensitive to extreme pH, high temperatures, and other cellular stressors. At a concentration of 2.5 ng/ml, EDF effectively induces cell death, significantly reducing population size in certain E. coli cultures.