Cell Line

Human OCT3 TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing OCT3 (Organic cation transporter 3, SLC22A3). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Please note that an MTA needs to be signed prior to purchase of this product, we kindly request that you contact your local office. This product is provided at this price to academic organisations (not for profit).