Chemicals & Small Molecules

Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R). It has anticancer activity, inhibits ligand-dependent receptor activation and downstream signaling, and can be used in the study of non-small cell lung and prostate cancer.

Inclacumab (Anti-Human selectin P Recombinant Antibody) is a fully humanized IgG4 monoclonal antibody that selectively binds to P-selectin. Inclacumab inhibits platelet leukocyte aggregation induced by thrombin receptor-activating peptide (TRAP) or adenosine diphosphate (ADP). Inclacumab inhibits platelet leukocyte aggregation induced by thrombin receptor activating peptide (TRAP) or adenosine diphosphate (ADP).

IMAB027 (ASP1650) is a selective monoclonal antibody against CLDN6 (Claudin 6) with antitumor activity that induces death of CLDN6+ cancer cells through antibody-dependent and complement-dependent cytotoxicity.

Gatipotuzumab (PankoMab) is a novel humanized monoclonal antibody conjugated to the tumor-associated epitope of mucin 1 (TA-MUC1) with potential anti-tumor activity for the study of recurrent epithelial ovarian cancer.

Litifilimab (BIIB059) is a humanizedantibody targeting the plasma cell-like dendritic cell specific antigen (BDCA2) and C-type lectin structural domain family 4, member C (CLEC4C) for the study of cutaneous lupus erythematosus.

Subtilisin (EC 3. 4. 21. 14) is a bacterially derived serine protease that promotes hepatic LDL receptor (LDLR) degradation and can be used in the study of cardiovascular disease.

Phytohemagglutinin P (PHA-P) is a mitogen that selectively stimulates hematogenous or lymphoid monocytic cells [1].

Lavandoside is a compound derived from Helianthemum ruficomum with antioxidant activity.

M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in vitro and in vivo animal models. It is useful for research into nervous system diseases [1].