Chemicals & Small Molecules

Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.

NIR-797-isothiocyanate is a versatile dye employed extensively across various scientific and industrial sectors. As a critical tool in biological experiments, this dye enables the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, examination of tissue pathology, and monitoring of microorganisms. Its applications extend from fundamental research to a broad spectrum of clinical diagnostics. Additionally, NIR-797-isothiocyanate finds usage in traditional industries like textile dyeing and in innovative areas including functional textile processing, food coloring, and dye-sensitized solar cells.

NTPO trisodium induces DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are mitigated by base excision repair (BER) but not by nucleotide excision repair (NER) [1].

Rose bengal lactone (C.I. Solvent Red 141) is a rose bengal lactone stain commonly used to stain the nuclei of plant and animal cells.

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE), a biotin reagent, is employed for labeling proteins on the external leaflet of intact exosomes and features an extended spacer arm between the biotin and the amine-reactive linker. This elongated linker is designed to mitigate steric hindrance, thereby enhancing labeling efficiency on the densely populated exosome surface [1] [2].

TI17 is a selective TRIP13 inhibitor with anticancer activity that inhibits the proliferation of multiple myeloma (MM) cells and induces cycle arrest and apoptosis in MM cells.

Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.

Pan-RAS-IN-2 (compound 6A) is a molecular glue that specifically targets RAS molecules, exhibiting significant inhibitory activity on the proliferation of RAS-mutated cell lines. It forms a ternary complex with cyclophilin A (CYPA) and RAS(ON) proteins, which blocks the downstream binding of RAF to RAS, thereby exerting antitumor effects.

PTPN2-IN-1 (compound 4) acts as a potent inhibitor of PTPN2, demonstrating an IC 50 of less than or equal to 5μM. It effectively inhibits the cell growth of B16F10.