Results for Chemicals ( 2140 )
Dimethylallyl thiolodiphosphate (DMASPP) is an analog of DMAPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.Provided as the tris-ammonium saltBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1. Phan R. M. and C. D. Poulter (2001). "Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors." The Journal of Organic Chemistry 66(20): 6705.2. Hosfield D. J. Y. Zhang et al. (2004). "Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis." Journal of Biological Chemistry 279(10): 8526-8529.3. Köksal M. et al. (2010). "Structure of Isoprene Synthase Illuminates the Chemical Mechanism of Teragram Atmospheric Carbon Emission." Journal of Molecular Biology 402(2): 363-373. 4. Miyamoto K. et al. (2014). "A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: Biochemical characterization and stru
Geranyl thiolodiphosphate (GSPP) is an analog of GPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound. GSPP is turned over by avian farnesyl diphosphate synthase (FPPase) more slowly than FPP and acts as a competitive inhibitor (KI = 24.8 μM).Provided as the tris-ammonium saltBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1. Phan R. M. and C. D. Poulter (2001). "Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors." The Journal of Organic Chemistry 66(20): 6705.2. Phan R. M. and C. D. Poulter (2000). "Synthesis of Geranyl S-Thiolodiphosphate. A New Alternative Substrate/Inhibitor for Prenyltransferases." Organic Letters 2(15): 2287.3. Kuzuyama T. J. P. Noel et al. (2005). "Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products." Nature 435(7044): 983.4. Koksal M. W. K. W. Chou et al. (20
Farnesyl thiolodiphosphate (FSPP) is an analog of FPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.Provided as the tris-ammonium saltBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1. Phan R. M. and C. D. Poulter (2001). "Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors." The Journal of Organic Chemistry 66(20): 6705.2. Hast M. A. C. B. Nichols et al. (2011). "Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens." Journal of Biological Chemistry 286(40): 35149-35162.3. Lee L. V. B. Granda et al. (2010). "Biophysical Investigation of the Mode of Inhibition of Tetramic Acids the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase." Biochemistry 49(25): 5366.4. Kirby J. et al. (2016). "Engineering a functional 1-deoxy-D-xylu
Propargyl-geraniol ((E E)-3 7-Dimethyl-8-(2-propargyloxy)-2 6-octadien-1-ol) is an alkyne-modified isoprenoid that acts as a chemical reporter of protein prenylation via "Click" chemistry.The alkyne-modified isoprenoids were developed by the Distefano group at the University of Minnesota as chemical reporters of protein prenylation. The isoprenoids readily penetrate mammalian cells and are used as substrates by prenyltransferases. The pendant alkyne can be derivatized with an azide-containing tag such as a fluorophore or biotin via a Cu(I) catalyzed “Click†reaction allowing the prenylated proteins to be identified and quantified.References1) A.J. DeGraw et al. “Evaluation of alkyne-modified isoprenoids as chemical reportersof protein prenylation†(2010) Chem. Biol. Drug Des. 76 460-47 doi: 10.1111/j.1747-0285.2010.01037.x2) B.P. Duckworth et al “Selective Labeling of Proteins by Using Protein Farnesyltransferase†(2007) ChemBioChem 8 98-105. DOI: 10.1002/cbic.200600
Juvenile Hormone III (JH III) is a sesquiterpanoid found in insects which regulates important physiological processes such as reproduction and metamorphosis. JH III is biosynthesized via the mevalonate pathway and is metabolized by JH esterase and JH epoxide hydrolase terminating the activity of the hormone. JH III has also been found in certain plants such as Cyperus iria and C. Aromaticus potentially acting as a protectant against insect herbivory.Storage-20 °C or belowReferences1) C. Helvig et al. “CYP15A1 the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allate†Proc. Nat. Sci. Acad. 2004 101(12) 4024–40292) J.A. Tillman S.J. Seybold R.A Jurenka R.A. et al. “Insect pheromones - an overview of biosynthesis and endocrine regulation.†Insect Biochemistry and Molecular Biology 1999 29(6) 481-514.3) Y.C. Toong D.A. Schooley & F.C.Baker. “Isolation of Insect Juvenile Hormone III from a plant†N
Bisepoxy Juvenile Hormone III (mixture of diastereomers) is a sesquiterpenoid biosynthesized via the mevalonate pathway in the ring-glands of higher dipterans.Juvenile Hormones are sesquiterpenoids found in insects that regulates important physiological processes such as reproduction and metamorphosis. Bisepoxy juvenile hormone III (JHB3) is biosynthesized via the mevalonate pathway in the ring-glands of higher dipterans (flies).References1) J.A. Tillman S.J. Seybold R.A Jurenka R.A. et al. “Insect pheromones - an overview of biosynthesis and endocrine regulation.†Insect Biochemistry and Molecular Biology 1999 29(6) 481-514.2) D.S. Richard S.W. Applebaum et al “Juvenile hormone bisepoxide biosynthesis in vitro by the ring gland of Drosophila melanogaster: a putative juvenile hormone in the higher Diptera†Proc. Nat. Sci Acad. 1989 86 (4) 1421-1425.3) K.S. Lefevere K.S. Lacey et al. “Identification and quantification of juvenile hormone biosynthesized by larval
Propargyl-farnesol is an alkyne-modified isoprenoid that acts as a chemical reporter of protein prenylation via "Click" chemistry.The alkyne-modified isoprenoids were developed by the Distefano group at the University of Minnesota as chemical reporters of protein prenylation. The isoprenoids readily penetrate mammalian cells and are used as substrates by prenyltransferases. The pendant alkyne can be derivatized with an azide-containing tag such as a fluorophore or biotin via a Cu(I) catalyzed “Click†reaction allowing the prenylated proteins to be identified and quantified.References1) A.J. DeGraw et al. “Evaluation of alkyne-modified isoprenoids as chemical reportersof protein prenylation†(2010) Chem. Biol. Drug Des. 76 460-47 doi: 10.1111/j.1747-0285.2010.01037.x2) A. Hosokawa et al “Evaluation of an alkyne-containing analogue of farnesyl diphosphate as a dual substrate for protein prenyltransferases†(2007) Int. J. Pep. Res. Ther. 13 345-354.DOI 10.1007/s10989-00
Isoprenoids and isoprenols are key metabolic intermediates for biosynthesis of steroids including cholesterol and hormones that regulate human reproduction or fertility and post-translational modifications of proteins in signal transduction pathways for cell division and regulation of vesicular trafficking.