Lipids & Polymers

TCO-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Tetrazine-PEG4-SS-NHS is a cleavable four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Lipid A monophosphoryl from Salmonella minnesota R595

DOG-IM4 is an ionizable lipid which is used to deliver mRNA by forming lipid nanoparticles (LNPs). DOG-IM4 can improve the thermostability of mRNA/LNP in combination with helper lipids.

C3-K2-E14 is a multi-ionizable amino-lipid featuring a central tertiary amine with two identical brranches and an n-propyl group. Each branch features a propanamide linking to a branched amine, each with two C14 arms and a hydroxyl. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.

Acid-PEG4-C2-Boc, a linker compound based on polyethylene glycol (PEG) and alkyl/ether, is utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) for inhibiting the mechanistic Target of Rapamycin (mTOR)[1].

Dde Biotin-PEG4-DBCO is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG4-Hydrazide is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

BCN-PEG3-VC-PFP ester, a three-unit PEG ADC linker, is cleavable and commonly used in the synthesis of antibody-drug conjugates (ADCs) [1].