Lipids & Polymers

Tert-butyl (2-(pyridin-2-yldisulfanyl)ethyl)carbamate consists of a tert-butyl group, where the protected amine can be deprotected under mild acidic conditions, and the other part of the molecule may act as a thiol-specific labeling reagent, commonly used in reversibly binding cysteine residues on proteins.

(S)-2-(2-Aminopropanamido)acetic acid

sulfo-SPDB serves as a cleavable linker integral to the creation of antibody-drug conjugates (ADCs), where antibodies are linked to cytotoxins via this linker. ADCs are constructed by coupling antibodies with cytotoxic agents through the utilization of such linkers.

iso-TRAP-6 functions as a PAR-1 agonist, effectively stimulating platelets. It is an analog of TRAP-6, wherein the first amino acid has been replaced with isoserine.

N-(PEG4-acid)-N-bis(PEG4-t-butyl ester) is a branched PEG linker with a terminal carboxylic acid group which is reactive with amine molecules in the presence of HATU. The two t-butyl ester groups can be hydrolyzed under acidic conditions to obtain free acids.

N-(NHS-PEG3)-N-bis(PEG3-azide), HCl salt is a branched PEG linker containing a NHS ester that is reactive with amine-containing moieties and two azides highly reactive in click chemistry with strained cyclooctynes or other alkynes.

N-(PEG4-NHS ester)-N-bis(PEG4-t-butyl ester) represents a branched PEG linker containing two t-butyl ester moieties which can be deprotected under acidic conditions and an NHS ester moiety to react directly and efficiently with amine-containing entities.

N-(PEG4-NHS ester)-N-bis(PEG4-acid) is a branched PEG linker containing two terminal carboxylic groups which form stable amide bonds with amine-bearing compounds in the presence of HATU. The NHS ester reacts easily with primary amine groups. The PEG spacers impart water solubility.

L2, also known as nonadecanedioic acid,10-[[3-(dimethylamino)propyl](1-oxooctyl)amino]-,1,19-bis(2-hexyloctyl) ester, serves as an MC3 analogue used in the development of lipid nanoparticles (LNPs).