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GBD-9 is a dual-action degrader that effectively targets both BTK and GSPT1 for degradation by engaging the E3 ligase cereblon (CRBN). It functions as a PROTAC to promote BTK degradation while also serving as a molecular glue for GSPT1 degradation, demonstrating significant activity in inhibiting cancer cell proliferation.

PROTAC ERα Degrader-2 is composed of an IAP ligand binding group, a linker, and a binding group for estrogen receptor α (ERα), functioning as an effective degrader of ERα. It operates by utilizing cIAP1-based degradation inducers known as specific non-genetic IAP-dependent protein erasers (SNIPERs).

PROTAC TYK2 degradation agent 1 is a highly selective degrader for the TYK2 subtype, effectively inducing its degradation. This compound facilitates research into autoimmune conditions through its targeted action on TYK2.

SHP protein degrader-2 is a PROTAC designed to target and degrade the SHP2 protein, effectively lowering its expression in multiple cancer cell lines.

PP-C8 is a selective PROTAC that targets the degradation of the CDK12-Cyclin K complex. By facilitating the removal of these proteins, PP-C8 enhances the potential for synergistic effects when used in combination with PARP inhibitors, particularly in the context of triple-negative breast cancer.

VEGFR-2-IN-39 is a PROTAC designed to specifically target VEGFR-2, exhibiting low toxicity. This compound effectively inhibits the proliferation of EA.hy926 cells, a line derived from human umbilical vein endothelial cells, in a concentration-dependent manner. Its structural composition enables effective interaction with VEGFR-2, making it useful for studying vascular-related pathways.

PROTAC MDM2 Degrader-1 employs PROTAC technology to target and degrade MDM2. It consists of a potent MDM2 inhibitor linked to a ligand that interacts with E3 ubiquitin ligase, facilitating selective protein degradation. This structural design enhances the compound's ability to modulate protein levels effectively through targeted ubiquitination mechanisms.

PROTAC BRD9 Degrader-4 is a bifunctional degrader targeting BRD9, designed for use in cancer research. Its structural components enable effective protein degradation, facilitating the study of BRD9's role in cancer biology.

PROTAC BET Degrader-1 is a bifunctional molecule that links Cereblon and BET ligands, effectively reducing the levels of BRD2, BRD3, and BRD4 proteins. Its functional groups enable targeted protein degradation at low concentrations