PEG

PROTAC MDM2 Degrader-3 is an advanced MDM2 degrader utilizing PROTAC technology. This compound consists of a strong MDM2 inhibitor, a linking moiety, and an MDM2 ligand designed to engage with E3 ubiquitin ligase, facilitating targeted degradation of MDM2.

ARD-266 is a highly effective PROTAC degrader targeting the Androgen Receptor (AR) through von Hippel-Lindau E3 ligase. This compound facilitates the degradation of AR protein in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1. Featuring an alkyne functional group, ARD-266 also serves as a click chemistry reagent, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.

MG-277 is a molecular glue degrader that targets the translation termination factor GSPT1 via the Cereblon E3 ligase pathway. This compound effectively facilitates the degradation of GSPT1 and demonstrates significant inhibition of tumor cell growth in a p53-independent manner. Its structural features enable potent interactions with cellular components, contributing to its effectiveness in research settings focused on cellular regulation and potential therapeutic applications.

dTAG-47 is a heterobifunctional compound designed to target the mutant FKBP12, which functions as a degradation tag when fused to a protein of interest. This unique structure facilitates targeted protein degradation, making it a valuable tool for investigating basal-like breast cancers. Its bifunctional nature enhances selectivity and efficacy in protein modulation studies.

FC-11 is a PROTAC that targets focal adhesion kinase (FAK) for degradation. It features a Cereblon ligand from Pomalidomide, a linker, and a FAK ligand, PF562271. This compound effectively degrades FAK in various cell types, making it a useful tool for studying FAK-related signaling pathways.

Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].

Ald-CH2-PEG3-azide is a cleavable 3-unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Bis-PEG4-acid is a PEG PROTAC linker (PROteolysis TArgeting Chimera) used in targeted protein degradation applications.

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].