Results for PEG ( 6581 )
Methyltetrazine-PEG7-maleimide serves as a bifunctional PEG linker comprised of methyltetrazine, which is reactive toward trans-cyclooctenes, and maleimide, which is reactive towards thiol-bearing moieties. The additional methyl on the methyltetrazine enhances the stability of the group. The PEG link enhances solubility in aqueous media.
DOTA-PEG5-TCO is a PEG linker containing DOTA and TCO moieties. TCO is a click chemistry handle that readily reacts with tetrazine groups on a target molecule. The DOTA group can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques.
3,4-Dibromo-Mal-PEG2-Acid constitutes a PEG linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The carboxylic acid can react with primary amines in the presence of coupling agents such as EDC and HATU. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
PC Biotin-PEG8-NHS carbonate ester is useful for introducing a biotin moiety to amine-containing biomolecules directly and efficiently. The hydrophilic PEG arm provides better solubility to the labeled molecules in aqueous media. Captured biomolecules can be efficiently photoreleased using near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).
Picolyl azide-PEG4-NHS ester is a bifunctional PEG linker comprised of a picolyl moiety that assists with a copper-chelating system within its structure, lowering the amount of copper catalyst required in the CuAAC reaction for the azide and an NHS ester that directly and efficiently reacts with amine-bearing moieties. The PEG4 chain improves the compound's water solubility.