KB02-COOH is a fragment used in the synthesis of the ubiquitin E3 ligase ligand KB02. This ligand plays a role in the creation of PROTACs, enabling targeted protein degradation in compounds like KB02-JQ1 and KB02-SLF.
NV03 is a selective antagonist that disrupts the interaction between UHRF1 and H3K9me3 by binding to the UHRF1 tandem tumor domain. Its structural features make it valuable for studying UHRF1-related protein interactions.
cIAP1 ligand 1 is an IAP ligand derived from LCL161. It can be linked to an ABL-targeting ligand via a linker to form a SNIPER construct, enabling targeted protein degradation.
CRBN modulator-1 is a Thalidomide analog that functions as a cereblon (CRBN) modulator. Its structural properties make it useful for studying CRBN-related protein interactions.
E3 ligase Ligand 8 is a ligand that targets E3 ubiquitin ligase and can be linked to a protein-targeting ligand via a linker to create PROTACs. These structures facilitate ubiquitination-mediated protein degradation.
Cereblon inhibitor 1 is an isoindoline derivative which acts as a modulator of the cereblon E3 ubiquitin ligase. Its structural features make it valuable for studying cereblon-related protein interactions.
VH101, thiol is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal thiol group, designed for PROTAC development. It enables conjugation with a target protein-ligand for use in E3 ligase-mediated degradation systems.
E3 ligase Ligand 18 is designed to target E3 ubiquitin ligase and can be linked to a protein ligand via a connector to create PROTACs, which facilitate ubiquitin-mediated degradation of specific proteins.
