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Setidegrasib is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide-based PROTAC designed to target and degrade the G12D-mutant KRAS protein. Its structure enables selective recruitment of the mutant protein for proteasomal degradation.

ARD-61 is a highly potent and selective PROTAC designed to degrade androgen receptors (AR) and progesterone receptors (PR) in AR-positive cell lines. It contains an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it useful for click chemistry applications.

SJ988497 is a PROTAC molecule designed to degrade JAK2, effectively inhibiting cell proliferation in CRLF2-rearranged cell lines. It also promotes the degradation of the CRBN neosubstrate GSPT1. Structurally, it includes a Ruxolitinib derivative, a linker, and a CRBN ligand (Pomalidomide), making it useful for studying protein degradation mechanisms.

ZXH-4-130 is a potent and selective degrader of CRBN, functioning as a hetero-PROTAC compound that connects CRBN and VHL. Its structure facilitates targeted protein degradation. The salt form, ZXH-4-130 TFA, offers improved water solubility and stability compared to its free form, while maintaining similar biological activity.

PROTAC BRAF-V600E degrader-1 is a highly effective compound designed to target and degrade the BRAF-V600E protein through the ubiquitin-proteasome system (UPS). Its structure allows for selective binding to both BRAF and the BRAF-V600E variant, facilitating protein degradation.

SHP2-D26 is a pioneering and effective degrader of SHP2, operating through its binding interactions with both VHL-1 and SHP2 proteins. The mechanism of action relies on neddylation and the proteasome pathway for inducing SHP2 degradation.

KTX-951 is a PROTAC designed to selectively degrade IRAK4, demonstrating effective performance in cellular assays. This compound exhibits notable oral bioavailability in preclinical models, indicating its potential for effective systemic delivery. Additionally, KTX-951 shows promise in anticancer applications due to its mechanism of action.

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-target PROTAC that facilitates the ubiquitination and degradation of Smad3 while enhancing the levels of HIF-α protein. This compound exhibits multifunctional properties, contributing to anti-fibrosis effects and offering protective benefits for renal tissues, making it a valuable tool for research in renal anemia.

dBET23 is a potent and selective PROTAC designed to degrade the BRD4 protein. Its structural composition enables effective targeting of BRD4, facilitating its degradation through the ubiquitin-proteasome system. This compound's specificity makes it a valuable tool for studying BRD4-related biological processes.