PEG

7-O-(Amino-PEG4)-paclitaxel contains a paclitaxel moiety which is used a treatment for certain types of cancers. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer makes the compound more compatible in aqueous media.

7-O-(Amino-PEG4)-paclitaxel contains a paclitaxel moiety which is used a treatment for certain types of cancers. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer makes the compound more compatible in aqueous media.

7-O-(Amino-PEG4)-paclitaxel contains a paclitaxel moiety which is used a treatment for certain types of cancers. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer makes the compound more compatible in aqueous media.

Folate-PEG2-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

endo-BCN-PEG2-NH2 is a PEG-based linker for PROTACs that joins two essential ligands, critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Benzyl-PEG12-alcohol is a PEG-based linker for PROTACs, connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Rha-PEG3-SMCC (Compound 13) serves as an ADC (antibody-drug conjugate) linkage agent with robust antitumor properties, utilizing the protein crosslinker SMCC, which is tethered through the non-cleavable linker Rha-PEG3.

Ald-C2-PEG4-azide is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azide-PEG6-Tos is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.