Results for PEG ( 6339 )
Pomalidomide-PEG8-propargyl serves as a PROTAC linker featuring a Pomalidomide-based cereblon ligand that incorporates an E3 ligase ligand. The terminal propargyl is reactive with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry. The PEG8 chain improves the water-solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DSPE-PEG-Gly-Gly-Gly TFA salt, MW 2,000 functions as an active ester reactive polyPEG phospholipid containing a Gly-Gly-Gly tripeptide which can be used for conjugation. The 2k PEG polymer greatly improves the water solubility of the compound. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
PC Mal-PEG4-OH functions as a photocleavable PEG linker including a maleimide moiety which is thiol-reactive between pH 6.5 to 7.5. The PEG4 spacer increases the aqueous solubility of the compound and assists in fine-tuning DMPK properties. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
A cyclopropane fatty acid naturally found in bacterial cell membranes, seed oils, fermented foods, and dairy products. Studies suggest cyclopropane fatty acids are versatile cell membrane components that regulate membrane fluidity in response to environmental changes in pH and temperature (J. Phys. Chem. B 2015, 119, 17, 5487–5495) . Please contact us for the custom synthesis of any other cyclopropane fatty acids. Reagent grade, for research purpose. Please contact us for GMP-grade .
Mal-PEG4-Val-Cit-PAB-MMAF functions as a linker-payload construct with a thiol-specific maleimide which is used to label cysteine residues in proteins and an enzymatically cleavable Val-Cit site. The Val-Cit will specifically be cleaved by Cathepsin B. MMAF is a synthetic antineoplastic agent that may be employed as a cytotoxic payload. Solubility in aqueous media is enhanced via the PEG chain.
BP Lipid 440 is an analog of the ionizable lipid LP01 whose key feature is the introduction of an iso- methyl branched fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticle as methyl branched fatty acids have been reported to affect the fluidity and structure of lipid bilayers (J. Phys. Chem. B 2014, 118, 48, 13838–13848). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
DBCO-PEG10-amine constitutes a bifunctional PEG linker with DBCO and amine on either side, respectively. The DBCO group can be employed for copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The PEG spacer increases the solubility in aqueous media.